高月
国家高层次青年人才
研究方向：神经系统疾病的分子机制与治疗靶点
所在系部：神经科学研究所
邮 箱：yg@xmu.edu.cn
研究领域
主要致力于唐氏综合征、阿尔茨海默病等神经系统疾病的病理机制方面的研究，近期在Cell, Nature neuroscience等国际学术期刊上发表研究论文，解析了多个基因与神经系统疾病的关联性。利用疾病动物模型结合动物行为学、电生理、多组学分析等相关技术，深入阐明神经系统疾病的致病机制，为临床诊断和靶向药物的开发提供模型和理论依据。
学习经历
2017~2021 厦门大学医学院生理学专业 理学博士；
2014~2017 厦门大学医学院微生物学专业 硕士研究生；
2010~2014 长春理工大学生物工程专业 工学学士。
工作经历
2023~至今厦门大学医学院 教授；
2021~2023 厦门大学医学院 博士后。
代表性成果
1. Gao Y#, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang T, Zheng Q, Xu H, Wang X*. b2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function, Cell. 2023, 186: 1026-1038
2. Zhao Y#, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan X, Huang T, Wang Y, Huaxi Xu, Liu C, Wang X*. b2-Microglobulin coaggregates with Abeta and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice. Nat. Neurosci. 2023. 26, 1170–1184
3. Huo Y#, Gao Y#, Zheng Q, Zhao D, Guo T, Zhang S, Zeng Y, Cheng Y, Gu H, Zhang L, Zhu B, Luo H, Zhang X, Zhou Y, Zhang YW, Sun H, Xu H, Wang X*. Overexpression of human SNX27 enhances learning and memory through modulating synaptic plasticity in mice, Front Cell Dev Biol.2020, 8(8):0-595357
4. Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol. 2019;17(12): e3000525.
承担的重要课题
1. 国家自然青年科学基金项目, 82301358, β2-微球蛋白在缺血性脑卒中神经功能损伤中的功能和机制研究, 2024-01至2025-12，20万元,主持。
2. 国家自然科学基金委员会, 联合基金项目, U21A20358, β2-微球蛋白参与唐氏综合征认知障碍的功能与机制研究, 2022-01-01 至 2025-12-31, 260万元, 在研, 参与。
所有论文列表
1. Gao Y#, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang T, Zheng Q, Xu H, Wang X*. b2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function, Cell. 2023, 186: 1026-1038. PMID: 36868208
2. Zhao Y#, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan X, Huang T, Wang Y, Huaxi Xu, Liu C, Wang X*. b2-Microglobulin coaggregates with Abeta and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice. Nat. Neurosci. 2023. 26, 1170–1184. PMID:37264159
3. Huo Y#, Gao Y#, Zheng Q, Zhao D, Guo T, Zhang S, Zeng Y, Cheng Y, Gu H, Zhang L, Zhu B, Luo H, Zhang X, Zhou Y, Zhang YW, Sun H, Xu H, Wang X*. Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice. Front Cell Dev Biol. 2020;8:595357. PMID: 33330482
4. Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X*. Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability. Mol Psychiatry. 2022, 22: 1-14. PMID: 35338313
5. Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X*. Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25. Sci Adv. 2021;7(1): eabe1340. PMID: 33523861
6. Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol. 2019;17(12): e3000525. PMID: 31841517
7. Zhang H#, Zhu L#, Wang F#, Wang R, Hong Y, Chen Y, Zhu B, Gao Y, Luo H, Zhang X, Sun H, Zhou Y*, Yao Y*, Wang X*. Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAME-Like Syndrome Compromise Potassium Channel Function. Front Genet. 2019;10:912. PMID: 31781151
8. Zhong L#, Xu Y#, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF*. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.Nat Commun. 2019 Mar 25;10(1):1365. PMID: 30911003
9. Zhao D#, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, Wang X, Zhang J, Liu FR, Li Y, Bu G, Wen L, Huang TY, Xu H, Zhang YW*. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.Biol Psychiatry.2019 Aug 1;86(3):171-184. PMID: 30292394
10.Niu M#, Zheng N#, Wang Z#, Gao Y, Luo X, Chen Z, Fu X, Wang Y, Wang T, Liu M, Yao T, Yao P, Meng J, Zhou Y, Ge Y, Wang Z, Ma Q, Xu H, Zhang YW*. RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.Front Cell Dev Biol. 2020 Dec 8:8:598622. PMID: 33364235
11.Li Y#, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease.J Neurosci. 2017 Sep 20;37(38):9259-9268. PMID: 28842416
