吴荣 教授，博士生导师，国家级青年人才

厦门大学南强青年拔尖A类人才

研究方向：神经退行性疾病分子机理

邮    箱：rwu@xmu.edu.cn

研究领域

课题组围绕神经退行性疾病的发生发展机制开展研究，重点聚焦生物分子凝聚体及RNA稳态失调在神经系统病理过程中的作用。综合运用组学分析、CRISPR-Cas9功能筛选、高分辨率显微成像等前沿技术，结合人源多能干细胞模型、疾病动物模型与临床样本资源，从分子、细胞到在体水平系统解析关键致病机制，并探索潜在干预靶点与治疗策略。相关成果发表于Neuron、Cell Research、Advanced Science、Cell Death & Differentiation等杂志。主要研究方向：

1.神经退行性疾病中生物分子凝聚体稳态失调的分子机制及其靶向干预策略；

2.脑衰老及阿尔茨海默病相关RNA表征及其调控机制；

3.RNA结合蛋白在神经系统疾病发生发展中的功能与作用机制。

学习经历

2011~2016 中国科学院生物物理研究所 神经生物学专业 博士；

2007~2011 北京科技大学化学与生物工程学院生物技术专业 学士。

工作经历

2026~至今厦门大学医学院 教授；

2025~2026 美国约翰霍普金斯大学医学院生理、药理与治疗系 Research Associate；

2022~2025 美国约翰霍普金斯大学医学院生理系 博士后；

2019~2022 美国约翰霍普金斯大学医学院神经病理系 博士后；

2016~2019 军事科学院军事医学研究院脑中心博士后；

代表性成果

1.Du C#, Li Y#, Wu R#, Shen Y, Yang J, Xiao X, Zhou Y. 2026. Aberrant splicing signatures underpin oligodendrocyte damage in ALS and neuron Loss in FTD. Advanced Science, e14886.

2.Wu R, Ye Y, Dong D, Zhang Z, Wang S, Li Y, Wright N, Redding-Ochoa J, Chang K, Xu S, Tu X, Zhu C, Ostrow L, Roca X, Troncoso J, Wu B, Sun S. 2024. Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS. Neuron 112, 3434-3451.

3.Wu R, Sun S. 2024. Pathological RNA-protein inclusions and dysregulated A-to-I RNA editing in synucleinopathies. Neuron 112, 2459-2461.

4.Wu R#, Li A#, Sun B#, Sun J#, Zhang J#, Zhang T#, Chen Y, Xiao Y, Gao Y, Zhang Q, Ma J, Yang X, Liao Y, Lai W, Qi X, Wang S, Shu Y, Wang H, Wang F, Yang Y, Yuan Z. 2019. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research 29, 23–41.

5.Wu R, Chen H, Ma J, He Q, Huang Q, Liu Q, Li M, Yuan Z. 2016. c-Abl-p38alpha signaling plays an important role in MPTP-induced neuronal death. Cell Death Differ 23, 542-552.

获奖及荣誉

1.国家高层次青年人才，2025年；

2.美国约翰霍普金斯大学医学院青年学者奖（W. Barry Wood Jr. Research Award），2025年。

所有论文列表

1.Wu R#, Sun J#, Wang J, Li B, Liu Q, Ning G, Jin W, Yuan Z. 2017. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. Diabetologia 60, 900-910.

2.Wu R, Liu X, Sun J, Chen H, Ma J, Dong M, Peng S, Wang J, Ding J, Li D, Speakman J, Ning G, Jin W, Yuan Z. 2017. DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discovery 3, 16054.

3.Li X, Yang P, Dong B, Jiang L, Xiu R, Guo J, Li S, Zhang P, Gu R, Li A, Zhang J, Wu R, Wang F, Shen Y, Shao N, Cheng J, Yuan Z. 2025. Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice, iScience, 113949.

4.Zhang Z, Fu X, Wright N, Wang W, Ye Y, Asbury J, Li Y, Zhu C, Wu R, Wang S, Sun S. 2025. PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD. Neuron 113, 1190-1205.

5.Dong D, Zhang Z, Li Y, Latallo M, Wang S, Nelson B, Wu R, Krishnan G, Gao F, Wu B, Sun S. 2024. Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons. Science Signaling 17, eadl1030.

6.Zhang Y, Song Z, Wu R, Kong X, Zhang H, Li S, Gong X, Gong S, Cheng J, Yuan F, Wu H, Wang S, Yuan Z. 2024, PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Reports 43, 113930.

7.Latallo MJ#, Wang S#, Dong D#, Nelson B, Livingston NM, Wu R, Zhao N, Stasevich TJ, Bassik MC, Sun S, Wu B. 2023. Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD. Nature Communications 14 (1), 5581.

8.Li Y#, Dou X#, Liu J#, Xiao Y#, Zhang Z, Hayes L, Wu R, Fu X, Ye Y, Yang B, Ostrow L, He C, Sun S. 2023. Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nature Neuroscience 26, 1328-1338.

9.Zhang J#, Sun J#, Xing X, Wu R, Zhou L, Zhang Y, Yuan F, Wang S, Yuan Z. 2022.c‐Abl‐induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells. Glia. 70 (6), 1084-1099

10.Gao Y#, Chen X#, He Q, Gimple RC, Liao Y, Wang L, Wu R, Xie Q, Rich JN, Shen K, Yuan Z. 2020. Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin. PNAS 117 (52), 33295-33304.

11.Li X, Liao Y, Dong Y, Li S, Wang F, Wu R, Yuan Z, Cheng J. 2020. Mib2 deficiency inhibits microglial activation and alleviates ischemia-induced brain injury. Aging and disease 11(3), 523.

12.Ma J, Qi X, Yang C, Pan R, Wang S, Wu J, Huang L, Chen H, Chen J, Wu R, Liao Y, Mao L, Wang F, Wu Z, An J, Wang Y, Zhang X, Zhang C, Yuan Z. 2018.Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors. Molecular Psychiatry 23, 883-891.

13.Cheng J, Liao Y, Xiao L, Wu R, Zhao S, Chen H, Hou B, Zhang X, Liang C, Xu Y, Yuan Z. 2017. Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell Death Differ 24, 276-287.

14.Ma J, Wu R, Zhang Q, Wu J, Lou J, Zheng Z, Ding J, Yuan Z. 2014. DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J 462, 489-497.

15.Yao J, Huang J, Hai T, Wang X, Qin G, Zhang H, Wu R, Cao C, Xi JJ, Yuan Z, Zhao J. 2014.Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs. Scientific reports 4 (1), 1-8

16.Zhang Q, Wu J, Wu R, Ma J, Du G, Jiao R, Tian Y. Zheng Z, Yuan Z. 2012. DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection. Biochem J 447, 261-269.

17.Wu J, Peng S, Wu R, Hao Y, Ji G, Yuan Z. 2012. Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression. Protein & Cell 3, 470-480.